Recently, a review of the relationship between temperamental traits and monoamine neurotransmitters indicated that DA contributes to the complex involvement of impulsivity, NS, and incentive motivation (Robbins, 2018). In rats, the low novelty trend is related to low extracellular DA levels of striatum, agreeing with human data (Mallo et al., 2007). Subsequent work reported in the midbrain low D2/3 receptor (D2/3–R) availability, which is associated with elevated DA release in the striatum, could predict impulsivity by using PET (Buckholtz et al., 2010). confirmed that individual differences in the function of dopamine might be the basis for humans to show the personality trait of NS (Dellu et al., 1996). The three dimensions are associated with three neurotransmitters, dopamine (DA), serotonin (5-HT), and norepinephrine (NA) (Cloninger, 1987, 1988). Cloninger divided personality into three dimensions, namely novelty seeking (NS), harm avoidance (HA), and reward dependence (RD). In fact, psychologists in the field of personality research have reached a consensus that personality is formed by interactions between heredity and environment (Roberts, 2018 Soliemanifar et al., 2018). Based on the theory of biological social personality, Cloninger developed the three-dimensional personality theory and its questionnaire (Tridimensional Personality Questionnaire TPQ), which shows that some dimensions of personality are heritable and related to neurobiological markers (Cloninger, 1987). These traits, the core component of personality, can reduce personal volatility and lead to undertaking specific and effective actions. Personality traits determine the basic behaviors of the individual, which are the relatively stable and persistent tendencies of the individual to act in certain ways (Roberts, 2009). Our results suggested that GPx-1 may be involved in the biological mechanisms and be a potential gene that influenced personality. GPx-1polymorphism is related to personality traits in healthy Chinese-Han subjects. No sex effect was observed for either genotype for rs1050450. Regarding sex stratification, there was a significant difference in the NS2 score ( X 2 = 8.232, p = .016) among women for rs1800668. While the results showed the rs1050450 was significantly associated with NS4 ( X 2 = 6.059, p = .048). Our data found a correlation between rs1800668 and novelty seeking (NS) subscale NS2 ( X 2 = 7.392, p = .025). Finally, the association between different genotypes and TPQ scores was performed using SPSS, p < .05 is seen as significant statistical significance. We detected the genotypes of selected two polymorphisms through PCR-RFLP after extracting DNA. 2 ml of EDTA-treated blood from each volunteer was taken meanwhile, personality traits were assessed by TPQ. In our study, 493 healthy Chinese-Han participants (male = 234, female = 259) were recruited. We decide to explore the relationships between them in healthy Chinese-Han subjects by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The impact of GPx-1 polymorphisms has been rarely explored in the field of personality traits. glutathione peroxidase 1 (GPx1) plays an important role in metabolic dopamine change and closely relates to neurological and psychiatric disorders. Cloninger developed the three-dimensional personality theory and Tridimensional Personality Questionnaire (TPQ), which shows that some dimensions of personality traits are heritable and related to neurotransmitters including dopamine.
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